James Brewer, M.D., Ph.D.
Associate Professor, Radiology and Neurosciences
Human Memory Laboratory
LJVPC Suite C212, MC 0949
La Jolla, CA 92093-0949
office tel: 858-534-1237
lab tel: 858-534-1227
Lab Website: http://hml.ucsd.edu/hml/
|High-Resolution Functional Imaging of Human Memory Processes|
|Our laboratory uses functional and structural magnetic resonance imaging (MRI) to study memory processes in volunteers with healthy memory and in patients with memory difficulties, such as in Alzheimer’s disease (AD). This research focuses upon the medial temporal lobe (MTL), which shows selective damage early in the course of AD. The laboratory studies the contributions to memory that are made by distinct MTL substructures and the interaction of these structures with other brain regions.|
McEvoy LK, Brewer JB (In Press) Quantitative structural MRI for early detection of Alzheimer’s disease. Expert Review of Neurotherapeutics.
Gimbel SI, Brewer JB. (In Press) Reaction time, memory strength, and fMRI activity during memory retrieval: Hippocampus and default network are differentially responsive during recollection and familiarity judgments. Cognitive Neuroscience
Pitts MA, Martinez A, Brewer JB, Hillyard SA (2010) Early stages of figure-ground segregation during perception of the face-vace. Journal of Cognitive Neuroscience. Epub ahead of print.
Hales JB, Brewer JB. (2010) Activity in the hippocampus and neocortical working memory regions predicts successful associative memory for temporally discontiguous events. Neuropsychologia 48(11):3351-9.
Murphy EA, Holland D, Donohue M, Hagler DJ Jr., Dale AM, Brewer JB, and The Alzheimer’s Disease Neuroimaging Initiative. (2010) Six-Month Neuroanatomical Change in MTL Structures is Associated with Subsequent Memory Decline in Elderly Controls NeuroImage 53(4):1310-7.
Seibert TS, Hagler DJ, Brewer JB (2010) Early parietal response in episodic retrieval revealed with MEG Human Brain Mapping Epub ahead of print
Israel SL, Seibert TM, Black ML, Brewer JB (2009). Going their separate ways: Dissociation of frontal and hippocampal activity during memory recollection and post-retrieval processing. Journal of Cognitive Neuroscience Mar 20, Epub ahead of print
Kovacevic S, Rafii MS, Brewer JB (2009) Fully-automated volumetry predicts decline in MMSE and CDR in patients with mild cognitive impairment Alzheimer’s Disease and Associated Dementias, 23:139-145.
Brewer JB, Magda S, Airress C, Smith ME (2009) Fully-automated volumetry for assessment of focal atrophy in Alzheimer’s disease. American Journal of Neuroradiology 3:578-80.
Hales JB, Israel SL, Swann NC, Brewer JB. (2009) Dissociation of frontal and medial temporal lobe activity in maintenance and binding of sequentially presented paired associates. Journal of Cognitive Neuroscience, 7, 1244-1254
Brewer JB and Moghekar A. (2002). Imaging the medial temporal lobe: exploring new dimensions. Trends in Cognitive Science, 6, 217-223.
Golby, AJ, Poldrack RA, Brewer JB, Spencer D, Desmond JE, Aron A P, Gabrieli JDE. (2001). Material-specific lateralization in the medial temporal lobe and prefrontal cortex during memory encoding. Brain, 124, 1841-1854.
Canli T, Zhao Z, Brewer JB, Gabrieli JD, Cahill L. (2000). Event-related activation in the human amygdala associates with later memory for individual emotional experience. Journal of Neuroscience. 20, RC99