University of California - San Diego
UCSD - Neurosciences Graduate Program

FACULTY

Senyon Choe

Structural Biology Laboratory

Email: choe@salk.edu
Lab Website: http://sbl.salk.edu/
CV

Research Description

Professor Senyon Choe joined the Salk Institute in 1993 as the first member of the Institute’s newly initiated Structural Biology Laboratory. Choe uses X-ray crystallography as a major tool to determine three-dimensional structures of biologically important molecules. He and his colleagues also study the relationship between a molecule’s fine structure and the functions it carries out.

Among Choe’s recent interests is the study of molecules that bind to specific cells to instruct them to carry out functions. An extension of this work will explore the possibility of designing new molecules that can be delivered specifically to modulate sick cells. His group also has done pioneering work on the molecular structure of an ion channel, important to many physiological functions ranging from heart rate to nerve cell communication.


Recent Publications

Choe, S. (2002) Potassium Channel Structures. Nature Reviews Neurosci., 3, 115-121.

Roosild, T., Miller, S., Booth, I., Choe, S. (2002) A mechanism of regulation for potassium flux mediated by conformational change. Cell, 109, 781-791.

Groppe, J., Greenwald, J., Wiater, E., Rodriguez-Leon, J., Economides, A., Kwaitkowski, W., Affolter, M., Vale, W., I.-Belmonte, J.-C., Choe, S. (2002) Structural basis of BMP signaling inhibition by Noggin, a novel cystine knot protein. Nature, 420, 636-642.

Greenwald, J., Groppe, J., Gray, P., Wiater, E., Kwiatkowski, W., Vale, W., Choe, S.. (2003) The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly. Mol Cell, 11, 605-17.

Zhou, W., Qian, Y., Kunjilwar, K., Pfaffinger, P.J., Choe, S. (2004) Structural Insights into the Functional Interaction of KChIP1 with Shal-Type K+ Channels. Neuron 41, 573-586.

Greenwald, J., Vega, M., Allendorph, G., Fischer, W., Vale, W., Choe, S. (2004) A flexible activin explains the membrane-dependent cooperative assembly of TGF-beta family receptors. Molecular Cell, 15

Roosild, T.P., Greenwald, J., Vega, M., Castronovo, S., Riek, R., and Choe, S. (2005) NMR Structure of Mistic, a Membrane-Integrating Protein for Membrane Protein Expression Science 307,1317-21.

Pegan, S., Arrabit, C., Zhou, W., Kwiatkowski, W., Collins, A., Slesinger, P., Choe, S. (2005) Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification. Nature Neuroscience. 8, 279-287.

 

Page last updated: July 14, 2009


Contact Information

Graduate Program in Neurosciences
University of California, San Diego

9500 Gilman Drive 0662
La Jolla CA 92093-0662
Phone: (858) 534-3377
Fax: (858) 534-8242
E-mail: neurograd@ucsd.edu



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