As a pediatric neuropsychologist, my research interests lie in brain-behavior relationships during development and on cognitive sequelae of damage to and diseases of the central nervous system in children. In my laboratory, we are currently focusing on two areas. The first is the degree of plasticity seen, following very early (pre- and perinatal), focal brain damage, in cognitive functions thought to be subserved by the frontal lobes in adults. We are particularly interested in seeing whether deficits in inhibitory and working memory functions follow patterns seen in adults, or whether significant reorganization or compensation occurs. We have also performed studies of memory and attention in children with early brain damage, specific language impairment, and genetic disorders. The second major focus is on patterns of neuropsychological deficits associated with HIV in children, and on methods of tracking cognitive functioning during clinical drug trials for children with HIV and metabolic disorders.
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Nichols, S., Trauner, D., Brugge, K., and Delis, D. (1993). Neuropsy-chological profile of Down Syndrome adults. Journal of Clinical and Experimental Neuropsychology 15: 86-87.
Pratt, R.D., Nichols, S.N., McKinney, N., Kwok, S., Dankner, W.M., and Spector, S. (1996). Virologic markers of Human Immunodeficiency Virus Type 1 in cerebrospinal fluid of infected children. The Jou
Nichols, S.L., Jones, W., and Trauner, D.A. (1998). The effect of early focal brain lesions on Category Test performance in children. Journal of the International Neuropsychological Society 4: 71.
Nichols, S.L., Mahoney, E., Sirois, P., Stehbens, J., Loveland, K., Bordeaux, J., and Amodei, N. (1999). HIV-associated changes in adaptive, emotional and behavioral functioning in children and adoles
Loveland, K.A., Stehbens, J., Mahoney, E.M., Sirois, P., Nichols, S., Bordeaux, J.D., Watkins, J., Amodei, N., Hill, S., and Donfield, S. (1999). Declining immune function in HIV-infected children and
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